Exendin-4 and Liraglutide Attenuate Glucose Toxicity-Induced Cardiac Injury through mTOR/ULK1-Dependent Autophagy

<div>Effect of exendin-4 (Exe) and liraglutide (LIRA) on glucose toxicity-induced loss of mitochondrial membrane potential (MMP) assessed using JC-1: (a) representative fluorescent images of JC-1 staining depicting aggregates (red fluorescence), monomer (green fluorescence), and merged (yellow fluorescence), scale <span class="nowrap"><svg height="12.6656pt" id="M25" style="vertical-align:-3.42945pt" version="1.1" viewbox="-0.0498162 -9.23615 64.8 12.6656" width="64.8pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M152 404V712C115 698 54 683 7 677V654C71 648 73 642 73 579V24C128 -2 179 -12 220 -12C353 -12 471 92 471 238C471 357 381 449 274 449C262 449 249 446 233 439L152 404ZM152 374C170 384 202 393 230 393C313 393 382 326 382 213C382 97 330 26 246 26C194 26 165 62 158 81C154 91 152 101 152 116V374Z" id="g121-96"></path></g><g transform="matrix(.013,0,0,-0.013,6.669,0)"><path d="M433 39L423 65C413 59 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Exendin-4 and Liraglutide Attenuate Glucose Toxicity-Induced Cardiac Injury through mTOR/ULK1-Dependent Autophagy 