Curcumin Modulates DNA Methyltransferase Functions in a Cellular Model of Diabetic Retinopathy

Figure 4

Effects of curcumin on ROS production and DNMT function in ARPE-19 cells. (a) Comparison of ROS production in ARPE-19 cells, maintained either in normal or in high glucose conditions (acute and chronic exposure), and then exposed to 25 μM curcumin for 6 hours. (b) Comparison of total DNMT activity in ARPE-19 cells, maintained either in normal or in high glucose conditions (acute and chronic exposure), and then exposed to 25 μM curcumin for 6 hours. (c–e) Comparison of DNMT expression in ARPE-19 cells, maintained either in normal or in high glucose conditions (acute and chronic exposure), and then exposed to 25 μM curcumin for 6 hours. (f) Comparison of LINE-1 methylation level in ARPE-19 cells, maintained either in normal or in high glucose conditions (acute and chronic exposure), and then exposed to 25 μM curcumin for 6 hours. ; .

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