Intravitreal Injection of Hydrogen Peroxide Induces Acute Retinal Degeneration, Apoptosis, and Oxidative Stress in Mice

Figure 1

OCT analysis of the retina after the H₂O₂ treatment. (a) The schematic diagram of OCT analysis along the H₂O₂ treatment. (b–e) OCT images of the retina at days 0, 2, 7, and 14 of the H₂O₂ group. (f–i) OCT images of the retina at days 0, 2, 7, and 14 of the saline group. Retinal lesion was showed by a decreased in thickness of ONL and disruption of the PR both at days 7 and 14 after H₂O₂ exposure (d, e). (j) The total thickness of the retina showed a significant decrease after 7 days of H₂O₂ treatment and became more severe after 14 days. (k) The local thickness of the ONL also showed a significant decrease after 7 days of H₂O₂ treatment and more severe after 14 days ( from 3 mice). , compared to H₂O₂; , compared to day 0 within the H₂O₂ group. Scale bar: 200 μm.