Intravitreal Injection of Hydrogen Peroxide Induces Acute Retinal Degeneration, Apoptosis, and Oxidative Stress in Mice

Figure 2

Histological assessment of the retina after the H₂O₂ treatment. (a) The schematic diagram of histological analysis after the H₂O₂ treatment. (b) Representative of the retinae stained by hematoxylin and eosin. (c–f) Thickness of the retina, ONL, INL, and IPL after the H₂O₂ treatment. (c) Thickness of the retina was decreased at postinjection days 7 and 14 but not day 2. (d) Thickness of the ONL was decreased at postinjection days 7 and 14 but not day 2. (e) Thickness of the INL was decreased at postinjection days 7 and 14 but not day 2. (f) Thickness of the IPL was decreased at postinjection days 7 and 14 but not day 2. (–6 from 3 mice). , , and compared to the saline group. Scale bar: 200 μm. (g) Glial fibrillary acidic protein (Gfap; red) expression in the retina after the H₂O₂ treatment.

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