Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage

Figure 2

Changes in gene expression induced by sulforaphane in early passage, nonsenescent MRC-5 cells in vitro. Key: + 1 μM SFN (○▬○) and control, + 0.002% DMSO (●····●). (a) NQO1 (P = 2 × 10⁻⁴, , and ), (b) GCLM (, , and ), (c) GSR (, , and ), (d) HMOX1 (, , and ), (e) TXN (, , and ), (f) TXNRD1 (, , and ), (g) G6PD (, ), (h) TXT (, , and ), (i) TALDO (, , and ), (j) SQSTM1 (, , and ), (k) PSMA1 (), (l) PSMB5, (m) NFE2L2 (), (n) KEAP1 (), (o) MAFG (, , and ), (p) FYN (), (q) GLB1 (), (r) ELN (), (s) CTSO (), and (t) SREBF1 (, ). Data are , . Significance: , , and significance values for time, SFN treatment, and time × SFN treatment effects, respectively (); ANOVA repeated measures.

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