Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage

Figure 3

Effect of sulforaphane on gene expression in young and senescent MRC-5 fibroblasts in vitro. Key: solid bars, control; unfilled bars, +1 μM SFN. (a) NQO1 (, ), (b) GSR (, ), (c) TXN (, ), (d) TXNRD1 (, ), (e) FTH1 (, , and ), (f) HMOX1 (, ), (g) CAT (, , and ), (h) PDRX1 (), (i) GCLM (, ), (j) GSTP1 (), (k) SOD2 (), (l) NFE2L2 (, , and ), (m) KEAP1 (), (n) SQSTM1 (, , and ), (o) PSMA1 (), (p) PSMB5 (, ), (q) SREBF1 (), (r) FASN (), (s) CCL2 (, ), and (t) ICAM-1 (, ). Significance: , passage number effect; , +SFN effect; and , passage number × SFN effect; ANOVA repeated measures.

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