The Impact of Moderate Chronic Hypoxia and Hyperoxia on the Level of Apoptotic and Autophagic Proteins in Myocardial Tissue

Figure 2

Oxidative stress at the end of the exposure to 10% O₂, 21% O₂, and 30% O₂ for 28 days. (a) D-ROM (reactive O₂ metabolite) test to estimate the level of oxidant species in plasma, expressed in mgH₂O₂/dL (, 6, and 6, resp.). (b) The expression level of NADPH oxidase subunit 4 (NOX4) (, 6, and 5, resp.) and representative picture. The inset reports strong, inverse linear correlation; (a) the linear regression yielded , correlation coefficient , value = 0.0002; (b) the linear regression yielded , correlation coefficient , value = 0.023 and when significant is displayed with the 95% CI (dotted curves) and the slope . The ANOVA test value is reported in the figure. When significant , and represent and at the Tukey posttest, respectively.

(a)

(b)