The Impact of Moderate Chronic Hypoxia and Hyperoxia on the Level of Apoptotic and Autophagic Proteins in Myocardial Tissue

Figure 3

Hypoxia signaling: (a) expression level of hypoxia-inducible factor- (HIF-)1α after exposure to 10% O₂, 21% O₂, and 30% O₂ for 28 days (, 6, and 5, resp.) and representative picture; (b) expression level of hypoxia-inducible factor- (HIF-) 2α (, 6, and 6, resp.). The inset reports high, inverse linear correlation; (a) the linear regression yielded , correlation coefficient , value = 0.0075 and when significant is displayed with the 95% CI (dotted curves) and the slope . (b) no linear relationship. The ANOVA test value is reported in the figure. When significant , represent at the Tukey posttest.

(a)

(b)