Gossypol from Cottonseeds Ameliorates Glucose Uptake by Mimicking Insulin Signaling and Improves Glucose Homeostasis in Mice with Streptozotocin-Induced Diabetes

Figure 2

Effects of gossypol (GSP) on α-glucosidase activity. (a) Various concentrations of GSP or acarbose were incubated with the same units of α-glucosidase, and the degree of production of p-nitrophenol was measured spectrophotometrically at 405 nm. , , versus nontreated controls. (b) Lineweaver–Burk plot of α-glucosidase with GSP. Results are shown as mean values of 1/V, as inverses of increases in absorbance at 405 nm/min (ΔA₄₀₅ per min), and as the means of three independent tests at various PNPG concentrations.

(a)

(b)