Reactive Oxygen Species-Mediated Tumor Microenvironment Transformation: The Mechanism of Radioresistant Gastric Cancer

Figure 1

Radiotherapy and ROS promote antitumor effects. Radiotherapy irradiation causes cellular death through direct DNA breaks and indirect ROS effects. ROS induces 8-oxo-dGTP and 2-OH-dATP into genomic DNA, which leads to tumor cell apoptosis.