Age-Dependent Protective Effect of Selenium against UVA Irradiation in Primary Human Keratinocytes and the Associated DNA Repair Signature

Figure 1

SS age dependently increases resistance to UVA. Keratinocytes obtained from (a) young donors or (b) elderly donors were pretreated with 30 nM or 240 nM of SS. Then, the keratinocyte viability was determined using an MTT assay 24 h after exposure to increasing doses of UVA. Values are expressed as the mean ± SD of ( donors, 4 independent measurements for each age group), and we tested for statistical significance using Student’s t-test. and versus nontreated (nM SS) keratinocytes.

(a)

(b)