Swim Training Modulates Skeletal Muscle Energy Metabolism, Oxidative Stress, and Mitochondrial Cholesterol Content in Amyotrophic Lateral Sclerosis Mice

Figure 6

The Cav-1-dependent hypothesis of swim training-induced MAM modification leading to slowing down the development of the ALS disease. Under physiological conditions: appropriate levels of Cav-1 and cholesterol concentrations are presented in the skeletal muscle mitochondria. Progression of ALS is related to decreased Cav-1 level and increased cholesterol content in crude mitochondria, which leads to mitochondrial dysfunction, oxidative stress propagation, and ALS progression. Swim training induces the opposite effects, for example, increased Cav-1 levels and decreased cholesterol content in mitochondria, which finally have an effect on slowing down the development of the ALS disease.