Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 5967150, 10 pages
Research Article

Antiskin Inflammatory Activity of Black Ginger (Kaempferia parviflora) through Antioxidative Activity

1Korea Food Research Institute, Wanju-gun, 55365 Jeollabuk-do, Republic of Korea
2The Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA

Correspondence should be addressed to Tae-Gyu Lim;

Received 18 December 2017; Revised 16 January 2018; Accepted 5 February 2018; Published 3 April 2018

Academic Editor: Kota V. Ramana

Copyright © 2018 Myung-hee Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Kaempferia parviflora (Krachaidum (KD)) is a traditional herbal medicine and has properties that are beneficial for human health. In the current study, we sought to investigate the anti-inflammatory properties of KD extract (KPE). In mouse skin tissue, UV light representing solar wavelengths (sUV) increased COX-2 expression, while treatment with KPE reduced this effect. The anti-inflammatory activity of KPE was confirmed in in vitro models. MAPK signaling pathways were activated by sUV irradiation, and this was also repressed in the presence of KPE treatment. It is assumed that the anti-inflammatory activity of KPE is caused by the antioxidative effect. Furthermore, we confirmed the critical role of oxidative stress in sUV-induced COX-2 expression. We analyzed the polyphenol composition of KPE. Of the polyphenols identified, gallic acid, apigenin, and tangeretin were identified as the major polyphenols (at 9.31 ± 1.27, 2.37 ± 0.14, and 2.15 ± 0.19 μg/mg dry weight, resp.). Collectively, these findings show that in the presence of sUV irradiation, KD has anti-inflammatory properties and antioxidative effects in the skin.