Combined Therapy with Extracorporeal Shock Wave and Adipose-Derived Mesenchymal Stem Cells Remarkably Improved Acute Ischemia-Reperfusion Injury of Quadriceps Muscle

Figure 4

Histopathological finding of condensed collagen-deposition area in the quadriceps by day 7 after the IR procedure. (a–e) Illustrating the microscopic finding (200x) of Sirius red stain for identification of the condensed collagen-deposition area of the quadriceps (blue color). (f) Analytic result of condensed collagen-deposition area. versus other groups with different symbols (†, ‡, §, and ¶), . The scale bars in the lower right corner represent 50 μm. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test ( for each group). Symbols (, †, ‡, §, and ¶) indicate significance at the 0.05 level. HPF = high-power field; SC = sham control; IR = ischemia-reperfusion; ECSW = extracorporeal shock wave; ADMSC = adipose-derived mesenchymal stem cell.

(a)

(b)

(c)

(d)

(e)

(f)