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Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 6015351, 17 pages
Review Article

Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases

1Department of Clinical and Biological Sciences, University of Torino, Orbassano, Torino, Italy
2CCM Italia, Torino, Italy
3Proteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council, Napoli, Italy
4Plant Genetics and Breeding, Department of Agriculture, Forest and Food Sciences, University of Torino, Grugliasco, Torino, Italy

Correspondence should be addressed to Saverio Francesco Retta; ti.otinu@atter.ocsecnarf

Received 27 April 2018; Accepted 24 July 2018; Published 23 August 2018

Academic Editor: Daria M. Monti

Copyright © 2018 Andrea Perrelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oat (Avena sativa) is a cereal known since antiquity as a useful grain with abundant nutritional and health benefits. It contains distinct molecular components with high antioxidant activity, such as tocopherols, tocotrienols, and flavanoids. In addition, it is a unique source of avenanthramides, phenolic amides containing anthranilic acid and hydroxycinnamic acid moieties, and endowed with major beneficial health properties because of their antioxidant, anti-inflammatory, and antiproliferative effects. In this review, we report on the biological activities of avenanthramides and their derivatives, including analogs produced in recombinant yeast, with a major focus on the therapeutic potential of these secondary metabolites in the treatment of aging-related human diseases. Moreover, we also present recent advances pointing to avenanthramides as interesting therapeutic candidates for the treatment of cerebral cavernous malformation (CCM) disease, a major cerebrovascular disorder affecting up to 0.5% of the human population. Finally, we highlight the potential of foodomics and redox proteomics approaches in outlining distinctive molecular pathways and redox protein modifications associated with avenanthramide bioactivities in promoting human health and contrasting the onset and progression of various pathologies.