Blood and Tissue Enzymatic Activities of GDH and LDH, Index of Glutathione, and Oxidative Stress among Breast Cancer Patients Attending Referral Hospitals of Addis Ababa, Ethiopia: Hospital-Based Comparative Cross-Sectional Study
Table 3
Comparative mean analysis of serum enzymatic activities of GDH and LDH, concentration of glutathione, and the oxidative stress index of breast cancer (BCA) patients () and control group (), Addis Ababa, Ethiopia, 2015–2017.
Serum parameters
Control group
BCA patients
Mean diff.
value
95% CI
GDH (mU/l)
3.15 ± 0.69
4.20 ± 0.72
1.04
≤0.001
(0.8–1.3)
LDH (mU/l)
30.4 ± 32.6
78.6 ± 113
48.2
0.036
(3.4–92.9)
GSH (μM per μg of protein)
20.9 ± 2.6
10.2 ± 2.9
−10.7
≤0.001
(4.3–6.0)
GSSG (μM per μg of protein
0.2 ± 0.1
0.51 ± 0.2
0.31
≤0.001
(0.8–1.2)
TOS (μmol H2O2 Eq/l)
2.32 ± 1.0
2.75 ± 1.1
0.43
≤0.001
(0.39–1.27)
TAC (mmol Trolox Eq/l)
100.9 ± 29.8
83.5 ± 30.3
−13.65
0.017
(−24.7 to −2.6)
OSI (ratio of TOS/TAC100)
2.3 ± 1.5
3.3 ± 1.7
1.0
0.006
(0.32–1.67)
Total protein (μg/ml)
59.7 ± 29.3
208 ± 11.8
148.22
0.001
(143.56–152.87)
The mean difference is significant at value ≤ 0.05.
