Blood and Tissue Enzymatic Activities of GDH and LDH, Index of Glutathione, and Oxidative Stress among Breast Cancer Patients Attending Referral Hospitals of Addis Ababa, Ethiopia: Hospital-Based Comparative Cross-Sectional Study
Table 4
Comparative mean analysis of tissue enzymatic activities of GDH and LDH, concentration of glutathione, and the oxidative stress index of noncancerous tissues () and cancerous tissues (), Addis Ababa, Ethiopia, 2015–2017.
Tissue parameters
Normal tissue
Tumor tissue
Mean diff.
value
95% CI
GDH (mU/l)
0.92 ± 0.73
1.40 ± 0.88
0.5
0.011
(0.12–0.82)
LDH (mU/l)
70.5 ± 10.7
111.7 ± 23.2
41.2
0.009
(−7.5 to 89.9)
GSH (μM per μg of protein)
14.9 ± 2.7
11.03 ± 2.0
−3.87
0.029
(−0.2 to 0.8)
GSSG (μM per μg of protein)
0.21 ± 0.1
0.47 ± 0.3
0.26
0.003
(0.09–0.02)
TOS (μmol H2O2 Eq/l)
2.1 ± 0.9
3.5 ± 1.1
1.4
≤0.001
(0.33–1.22)
TAC (mmol Trolox Eq/l)
188.9 ± 26.7
161.6 ± 50.8
−27.32
0.01
(−47.42 to −7.2)
OSI (ratio of TOS/TAC100)
1.1 ± 0.5
2.15 ± 1.8
1.05
0.002
(0.3–1.22)
Total protein (μg/ml)
149.4 ± 54.2
194.9 ± 27.4
45.5
0.001
(34.7–56.4)
The mean difference is significant at value ≤ 0.05.
