Research Article
Uric Acid Protects against Focal Cerebral Ischemia/Reperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression
Figure 3
Effect of UA on oxidative injury in cerebral cortices in rats. (a) Quantification of MDA; data are means ± SE (). (b, c) Representative blot of protein oxidation. Quantification of carbonyl group bands; data are means ± SE (). (d) Representative photomicrographs of 8-OHdG immunostaining. Scale bar in all panels = 50 μm. (e) Quantification of 8-OHdG-positive cells; data are means ± SE (). (f) Schematic diagram of coronal brain section. The black rectangle in the ischemic ipsilateral parietal cortex of the penumbra represents the region selected for histology. vs. the sham group; vs. the vehicle-treated I/R group; , vs. the UA-treated I/R group.
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