Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing

Figure 1

Estrogen-sensitive miRNAs associated with cardiovascular ageing are classified according to their role in the three main mechanisms leading to cardiovascular ageing: cardiovascular remodeling, endothelial dysfunction, and inflammation. (↓) and (↑) indicates increased or decreased expression in cardiovascular tissues during ageing, respectively. Role of estrogens on the expression of represented miRNA is also represented; (−) and (+) indicates negative or positive regulation, respectively. Controversial findings dependent on expression in different tissues/cells are indicated as (↓↑) and (−/+).