Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing

Table 1

HRT-sensitive miRNAs involved in age-associated diseases in postmenopausal women; miRNAs related to disease and the tissue sample types used in the study are listed and the miRNA-related function and specific miRNA targets are shown.

Disease (tissue)	miRNA	Function (targets)	References
Osteoporosis (bone)	miR-127 and miR-136	Regulation of bone mass (COL1, ALP, RUNX2, and OC)	[114]
Osteoporosis (serum)	miR-30b-5p	Biomarker	[115]
Sarcopenia (skeletal muscle)	miR-182 and miR-223	Regulation of the insulin/IGF-1 pathway (IGF-1R and FOXO3A)	[116]
Obesity (adipose tissue)	miR-19a-3p	Adipocyte cell fate, death, and proliferation (ESR1, AKT1, BCL2, BRAF, and CCND1)	[117]
Inflammageing (Serum)	miR-21 and miR-146a	Biomarker	[121]