Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing

Table 2

Circulating miRNAs associated with estrogen levels and/or ageing.

miRNA	Ageing	Estrogen	Sample/model	References
miR-126	−		Blood samples from centenarians	[133]
miR-126-3p	−		Plasma from healthy people	[134]
miR-126-3p		+	Serum from healthy women	[127]
miR-126-5p	+		Serum exosomes from postmenopausal women	[122]
miR-106b	−		Serum from older women	[137]
miR-106b-5p		+	Serum from HRT-treated postmenopausal women	[122]
miR-30b-5p		+	Serum samples from ovariectomized rats	[115]
miR-23a		−	Serum from female rats	[166]
miR-144		+	Serum from HRT-treated postmenopausal women	[122]
miR-146a		−	Serum from HRT-treated postmenopausal women	[121]
miR-21	+		Plasma from elderly people	[183]
	+	−	Serum from HRT-treated and non-HRT-treated postmenopausal women	[121]

Positive or negative associations with ageing and estrogens are represented, and the sample type or model used in each study is shown. HRT: hormone replacement therapy.