mTOR Modulates Methamphetamine-Induced Toxicity through Cell Clearing Systems

Figure 1

METH increases the amount of unstained vacuoles dose- and time-dependently. (a) Dose-dependent representative pictures of unstained vacuoles (arrows) of control and METH at 72 h treated cells at different doses. (b) Dose-dependent graph of unstained vacuoles per cell at 72 h. (c) Time-dependent representative pictures of unstained vacuoles (arrows) of control and 1 μM METH-treated cells. (d) Time-dependent graph of unstained vacuoles per cell of control and 1 μM METH-treated cells. (e) Time-dependent representative pictures of unstained vacuoles (arrows) of control and 10 μM METH-treated cells. (f) Time-dependent graph of unstained vacuoles per cell of control and 10 μM METH-treated cells. Values are given as the mean number of unstained vacuoles, which were counted in 50 cells per group. Error bars represent the standard error of the mean. vs. control; vs. other groups. N = nucleus. Scale bar = 1 μm.

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