Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases

Figure 1

Schematic representation of various subunits of mTORC1 and mTORC2 complex and its upstream signaling regulators and cellular function. The mammalian target of rapamycin (mTOR); insulin growth factor (IGF); adenosine monophosphate activated protein kinase (AMPK); eukaryotic translation initiation factor 4E- (eIF4E-) binding protein 1 (4EBP1); proline-rich AKT substrate 40 (PRAS40); tuberous sclerosis protein ½ (TSC1/2); Ras homolog enriched in brain (Rheb); phosphoinositide 3 kinase (PI3K); Unc-51 like autophagy activating kinase (ULK); ribosomal protein S6 kinase beta-1 (S6K1); forkhead box O transcription factor (FOXO); serum/glucocorticoid-regulated kinase 1 (SGK1); peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α).