Review Article

Nanoparticles in Medicine: A Focus on Vascular Oxidative Stress

Figure 2

The Nox 4 paradox. Vascular Nox 4 generates superoxide anion (O2āˆ’) and hydrogen peroxide (H2O2). Depending on which via predominates, Nox 4 activation can be damaging or protective. VSCMs: vascular smooth muscle cells.