Dietary DHA/EPA Ratio Changes Fatty Acid Composition and Attenuates Diet-Induced Accumulation of Lipid in the Liver of ApoE^−/− Mice

Table 4

General and biochemical parameters in serum and liver tissues.

	ND	HFD	DHA/EPA = 2 : 1	DHA/EPA = 1 : 1	DHA/EPA = 1 : 2
Serum parameters
TC (mM)	9.50 ± 0.46	19.38 ± 0.66^a	5.43 ± 0.52^a,b	7.82 ± 0.84^b,c	10.29 ± 0.31^b,c,d
TG (mM)	1.19 ± 0.05	2.38 ± 0.24^a	0.58 ± 0.05^a,b	0.75 ± 0.08^a,b	1.30 ± 0.07^b,c,d
LDL (mM)	3.51 ± 0.19	7.03 ± 0.46^a	2.55 ± 0.43^b	4.17 ± 0.40^b,c	4.34 ± 0.17^a,b,c
HDL (mM)	0.30 ± 0.03	0.13 ± 0.03^a	0.26 ± 0.03^a,b	0.35 ± 0.05^b	0.21 ± 0.01^a,b,d
Adiponectin (pg/mg)	159.76 ± 23.19	81.64 ± 8.36^a	196.77 ± 18.68^b	114.91 ± 14.16^c	103.97 ± 7.43^b,c
OX-LDL (μg/L)	223.46 ± 25.32	269.00 ± 14.73	171.58 ± 8.58^b	165.90 ± 8.29^b	165.89 ± 10.76^a,b
AST (U/L)	143.79 ± 21.97	487.5 ± 95.19^a	63.62 ± 7.36^a,b	110.23 ± 13.31^b,c	138.32 ± 28.99^b,c
ALT (U/L)	72.92 ± 9.06	210.82 ± 23.72^a	40.69 ± 4.88^a,b	51.67 ± 3.05^a,b	93.06 ± 13.03^b,c,d
AKP (U/L)	48.94 ± 5.18	90.66 ± 7.22^a	42.08 ± 3.50^b	58.93 ± 5.92^b,c	70.34 ± 4.55^a,b,c
Liver parameters
TC (mM/g protein)	74.94 ± 3.62	144.57 ± 4.72^a	73.81 ± 4.22^b	83.72 ± 3.30^b,c	77.59 ± 6.03^b
TG (mM/g protein)	204.01 ± 25.74	231.19 ± 14.54	125.21 ± 14.26^a,b	114.81 ± 7.32^a,b	160.34 ± 15.76
MDA (μM/g protein)	1.75 ± 0.17	2.31 ± 0.18^a	1.81 ± 0.14^b	1.73 ± 0.07^b	1.90 ± 0.08
SOD (U/mg protein)	6.2 ± 0.32	5.79 ± 0.16	6.9 ± 0.14^b	6.85 ± 0.03^a,b	6.86 ± 0.26^b
GSH (μM/g protein)	19.46 ± 2.37	10.8 ± 1.57^a	21.9 ± 2.59^b	23.81 ± 1.86^b	24.33 ± 2.69^b

Data are given as mean ± SEM, . ^a versus the ND group; ^b versus the HFD group; ^c versus the DHA/EPA = 2 : 1 group; ^d versus the DHA/EPA = 1 : 1 group.