Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology

Figure 6

Crystallographic structure of human 3-mercaptopyruvate sulfurtransferase (MST). (a) Cartoon representation of human MST monomer (PDB ID: 4JGT; 2.16 Å resolution) cocrystallized with its substrate 3-mercaptopyruvate (3-MP). (b) Zoom-in into the catalytic persulfidated Cys₂₄₈ (CysSSH₂₄₈; human MST numbering) site, after reaction with 3-MP. Pyruvate, a by-product of the reaction of MST with 3-MP, is represented in green sticks. Figure generated with PyMol 1.8.2.0 [238].