Transduced PEP-1-Heme Oxygenase-1 Fusion Protein Attenuates Lung Injury in Septic Shock Rats

Figure 8

Effects of PEP-1-HO-1 fusion protein on the expression of nuclear factor-kappaBp65 (NF-κBp65), phosphorylated NF-κBp65 (p-NF-κBp65), and Toll-like receptor 4 (TLR4) in lung tissues. (a) The expressions of NF-κBp65, p-NF-κBp65, and TLR4 in lung tissues were detected by Western blot analysis. (b) p-NF-κBp65 expression. (c) NF-κBp65 expression. (d) TLR4 expression. Data are expressed as mean ± SEM; rats per group. versus the sham group, versus the CLP group, and versus the LD group. CLP: cecal ligation and puncture; LD: CLP + low-dose PEP-1-HO-1 fusion protein; HD: CLP + high-dose PEP-1-HO-1 fusion protein.

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