Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo

Figure 4

Effect of PBM on keratinocyte survival and oxidative stress induced by exposure to 5-FU (0.1 mg/ml). (a) MTT assay showing the percentage of living cells in the absence of any treatment (not treated, NT) and after exposure to either PBM, 5-FU, or their combination. (b) ROS production (normalized to the percentage of living cells) in the absence of any treatment (not treated, NT) and after exposure to either PBM, 5-FU, or their combination. (c) Levels of HMOX1 gene expression in the absence of any treatment (not treated, NT) and after exposure to either PBM, 5-FU, or their combination. (d) Levels of SOD2 gene expression in the absence of any treatment (not treated, NT) and after exposure to either PBM, 5-FU, or their combination. Mann–Whitney test ; Mann–Whitney test . Data are the means ± SD.

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