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Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 6709742, 9 pages
https://doi.org/10.1155/2018/6709742
Research Article

Role of Exercise-Induced Cardiac Remodeling in Ovariectomized Female Rats

1Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary
2Department of Orthopaedics, University of Debrecen, Debrecen, Hungary
3Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary

Correspondence should be addressed to Anikó Pósa; uh.degezs-u.oib@okinap

Received 25 August 2017; Revised 21 November 2017; Accepted 8 January 2018; Published 13 February 2018

Academic Editor: Undurti N. Das

Copyright © 2018 Renáta Szabó et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myocardial extracellular matrix (ECM) is essential for proper cardiac function and structural integrity; thus, the disruption of ECM homeostasis is associated with several pathological processes. Female Wistar rats underwent surgical ovariectomy (OVX) or sham operation (SO) and were then divided into eight subgroups based on the type of diet (standard chow or high-triglyceride diet/HT) and exercise (with or without running). After 12 weeks, cardiac MMP-2 activity, tissue inhibitor of metalloproteinase-2, content of collagen type I, the level of nitrotyrosine (3-NT) and glutathione (GSH), and the ratio of infarct size were determined. Our results show that OVX and HT diet caused an excessive accumulation of collagen; however, this increase was not observed in the trained animals. Twelve weeks of exercise promoted elevation in the levels of 3-NT and GSH and similarly an increase in MMP-2 activity of both SO and OVX animals. The high infarct-size ratio caused by OVX and HT diet was mitigated by physical exercise. Our findings demonstrate that ovarian estrogen loss and HT diet caused collagen accumulation and increased ratio of the infarct size. However, exercise-induced cardiac remodeling serves as a compensatory mechanism by enhancing MMP-2 activity and reducing fibrosis, thus minimizing the ischemia/reperfusion injury.