Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology

Figure 1

GK diabetic rats displayed abnormalities related to metabolic control and muscle mass and strength. (a) GK rats fasted for 16 h had significantly impaired glucose tolerance as typified by higher AUC values relative to corresponding controls. (b and c) Fasted blood glucose and plasma insulin levels were used to quantify HOMA-IR (b) and HOMA-β (c) in control and GK rats. (d and e) Muscles were normalized to body weight. (f) Immunoblot and quantification of MyHC protein in gastrocnemius muscles of control and GK diabetic rats. (g) Grip strength of control and GK rats was normalized to body weight. Abbreviation: C: control; D: diabetic. Values are for at least 6 animals/group. Significantly different from corresponding control values at .

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