Research Article
Redox Balance, Antioxidant Defense, and Oxidative Damage in the Hypothalamus and Cerebral Cortex of Rats with High Fat Diet-Induced Insulin Resistance
Table 1
Effect of 8-week HFD on body weight, BMI, glucose, insulin, HOMA-IR, food and energy intake, and total protein concentration.
| | C () | HFD () |
| | Final body weight (g) | 312.2 ± 15.2 | 378.1 ± 17.6 | | BMI (g/cm2) | 0.52 ± 0.1 | 0.66 ± 0.3 | | Fasting glucose (mg/dL) | 99.8 ± 4.5 | 169.6 ± 15.1 | | Fasting insulin (μU/mL) | 4.7 ± 0.3 | 54.6 ± 4.1 | | HOMA-IR index | 1.4 ± 1.2 | 21.3 ± 1.6 | | Plasma FFA (μmol/L) | 79.5 ± 10.7 | 174.3 ± 10.2 | | Food consumption (g/day) | 23.2 ± 0.8 | 17.1 ± 0.6 | | Energy intake (kJ/day) | 266.2 ± 3.2 | 338.9 ± 5.1 | | Cerebral cortex total protein content (μg/mL) | 2515.0 ± 94.9 | 2159.0 ± 44.2 | | Hypothalamus total protein content (μg/mL) | 1892.0 ± 121.7 | 1616.0 ± 66.4 |
|
|
FFA, free fatty acids; HOMA-IR, homeostatic model assessment of insulin resistance; HFD, high fat diet. Differences statistically important at . |
