c-Met Signaling Protects from Nonalcoholic Steatohepatitis- (NASH-) Induced Fibrosis in Different Liver Cell Types

Figure 6

c-Met expression is decreased in NASH patients. (a) c-Met expression of intrahepatic nonclassical human monocytes analyzed by flow cytometry correlated with the NAFLD activity score (NAS). (b) c-Met expression on nonparenchymal (NP) cells of patients with HBV (hepatitis B virus), HCV (hepatitis C virus), PBC (primary biliary cholangitis), PSC (primary sclerosing cholangitis), C2 (alcoholic) cirrhosis, and NASH was analyzed by immunohistochemistry. Immunohistochemical staining of c-Met on liver sections of patients with (c) HCV-related cirrhosis and (d) NASH cirrhosis.

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