Table 5: Micronucleus (MN), nucleoplasmic bridge (NPB), nuclear buds (NBUD), and binucleated (BN) cell frequencies, telomere length (bp), and % of global DNA methylation for nonexposed and exposed groups according to MTHFR and TERT polymorphisms. Data presented as error (SE).

ParametersMTHFR (rs1801133)aTERT (rs2736100)b
CC ()CT/TT ()GG ()GT/TT ()

CBMN
Micronucleusc
 Nonexposed3.2 ± 0.7 (16)2.6 ± 0.4 (23)0.4272.6 ± 0.5 (11)2.9 ± 0.5 (28)0.766
 Exposed5.0 ± 0.8 (10)6.2 ± 0.6 (28)0.3077.6 ± 1.4 (7)4.9 ± 0.5 (32)0.029
Nucleoplasmic bridgec
 Nonexposed2.2 ± 0.4 (17)2.7 ± 0.7 (23)0.5552.2 ± 0.6 (11)2.7 ± 0.5 (28)0.589
 Exposed6.6 ± 0.7 (10)4.7 ± 0.5 (28)0.0345.0 ± 1.0 (7)5.5 ± 0.5 (32)0.641
NBUDc
 Nonexposed1.5 ± 0.4 (17)2.2 ± 0.5 (23)0.4392.0 ± 0.5 (11)2.0 ± 0.6 (28)0.937
 Exposed4.7 ± 0.4 (10)3.0 ± 0.3 (28)0.0133.6 ± 0.6 (7)3.1 ± 0.3 (32)0.535
Binucleated cellsd
 Nonexposed56.3 ± 7.0 (17)38.1 ± 3.9 (20)0.04649.5 ± 7.1 (12)44.9 ± 4.9 (28)0.616
 Exposed106.7 ± 18.6 (10)121.8 ± 9.6 (28)0.441135.3 ± 15.0 (7)115.1 ± 9.7 (31)0.359
Telomere length
 Nonexposed4266 ± 150.7 (16)5497 ± 468.4 (23)0.0535824 ± 713.9 (11)4392 ± 125.1 (28)0.049
 Exposed3918 ± 206.9 (10)4406 ± 200.3 (28)0.1644504 ± 765.9 (7)4161 ± 122.4 (31)0.656
Global DNA methylation
 Nonexposed3.779 ± 0.34 (16)3.821 ± 0.26 (23)0.9223.659 ± 0.32 (10)3.862 ± 0.26 (25)0.662
 Exposed2.784 ± 0.24 (10)3.335 ± 0.14 (28)0.0492.596 ± 0.26 (5)3.075 ± 0.12 (30)0.161

a value between the CC genotype and the combination CT/TT within groups; b value between the GG genotype and the combination GT/TT within groups; cevaluated in 1000 BN cells per individual; devaluated in 500 cells per individual.