Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats

Figure 5

Beneficial effect of RC on hepatic glucose and lipid metabolism signalling pathways. RC prevents hepatic damages associated to NAFLD through different mechanisms: (a) promotes oxidative balance: ROS, prooxidant p22phox, Erk1/2, and Nrf2 degradation inhibitions; (b) improves insulin sensitivity: inhibits IRS1^Ser-phosphorylation; (c) normalises SIRT1 levels and promotes its beneficial effects; (d) NF-κB and inflammatory pathway attenuation; (e) increases β-fatty acid oxidation and gluconeogenesis: PPARα stimulation, PPARγ, and adipogenesis inhibitions; (f) reduces de novo lipogenesis: maintains SREPB1c, ChREBP, and SREPB2 physiological levels, decreases hepatic triglycerides and cholesterol; (g) increases glycogenogenesis rate: GS expression normalisation; (h) ameliorates plasma adipokine and lipid contents. u: ubiquitin; ---: interpathway interactions; →: stimulatory activity; ┤: inhibitory activity; X: suppression.