Matrine Attenuates D-Galactose-Induced Aging-Related Behavior in Mice via Inhibition of Cellular Senescence and Oxidative Stress

Figure 2

MAT effects on D-gal-induced memory impairment in the novel object recognition test. MAT (2 and 10 mg/kg, oral) was administrated to D-gal-treated mice. D-gal was injected at a dose of 150 mg/kg for six weeks (s.c.). (a) Time spent on the object in seconds and (b) object recognition index were observed. Results are presented as . , , , and , differences between recognition index in the training and test session. Control received 2% ethanol in saline + saline, D-gal received 2% ethanol in saline + 150 mg/kg D-gal, VE-100 received 100 mg/kg VE + 150 mg/kg D-gal, M-2 received 2 mg/kg matrine + 150 mg/kg D-gal, and M-10 received 10 mg/kg matrine + 150 mg/kg D-gal.

(a)

(b)