Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress

Figure 3

(a–d) Transverse section of seminiferous tubules. (a) Normal appearance of seminiferous tubules in control rats. (b) Mild central degeneration in seminiferous tubules (arrowhead) in 5 mg/kg trazodone-administered rats. (c) Deformation in the basement membrane of seminiferous tubules (arrowhead) and large vacuoles (arrow) in germinal epithelium in 10 mg/kg trazodone-administered rats. (d) Seminiferous tubules with total degeneration (arrow) in 20 mg/kg trazodone-administered rats.

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