Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress

Table 1

Effects of TRZ on relative organ weights of male rats.

	C	TRZ-5	TRZ-10	TRZ-20
Relative left testis weights (g/100 g BW)	0.49 ± 0.01	0.51 ± 0.02	0.50 ± 0.01	0.50 ± 0.01
Relative left epididymis weights (g/100 g BW)	0.20 ± 0.004	0.20 ± 0.004	0.22 ± 0.004	0.19 ± 0.02

C: control group; TRZ-5: 5 mg kg⁻¹ trazodone-treated rats for the 28-day group; TRZ-10: 10 mg kg⁻¹ trazodone-treated rats for the 28-day group; TRZ-20: 20 mg kg⁻¹ trazodone-treated rats for the 28-day group. All data were expressed as mean ± standard error.