Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress

Table 4

Effects of TRZ on serum hormone levels of male rats.

	C	TRZ-5	TRZ-10	TRZ-20
FSH (IU/l)	32.50 ± 2.61	48.48 ± 2.34	58.54 ± 1.31	59.97 ± 4.00
LH (mg/dl)	5.77 ± 0.12	5.17 ± 0.39	9.07 ± 0.37	11.03 ± 0.78
Testosterone (IU/l)	2.53 ± 0.23	3.40 ± 0.16	3.68 ± 0.17	3.84 ± 0.12

C: control group; TRZ-5: 5 mg kg⁻¹ trazodone-treated rats for the 28-day group; TRZ-10: 10 mg kg⁻¹ trazodone-treated rats for the 28-day group; TRZ-20: 20 mg kg⁻¹ trazodone-treated rats for the 28-day group. All data were expressed as mean ± standard error. Different from C (). Different from C ().