Protocatechuic Acid Attenuates Trabecular Bone Loss in Ovariectomized Mice

Figure 1

Effects of PCA on changes of body weight and uterus weight in OVX mice. Sham or OVX mice were orally administered vehicle or PCA (10 and 20 mg/kg b.w./day) for 12 weeks. As a positive control group, E₂ (0.1 mg/kg b.w./day) was administered three times a week for 12 weeks via i.p. injection. Body weight was measured once a week (a). At the end of the experiment, the uterus was removed and weighed (b). Results are expressed as relative ratio per body weight. Data are mean ± SD (each group, ). between the sham and OVX-alone group. among OVX groups with or without interventions. among OVX groups with interventions. b.w.: body weight; i.p.: intraperitoneal; E₂: 17β-estradiol; OVX: ovariectomized; PCA: protocatechuic acid.

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