SIRT3: A New Regulator of Cardiovascular Diseases

Table 1

Known targets of SIRT3 and function.

Function	Gene symbol	Gene name	References
Energy metabolism
Glycolysis	PPID	Peptidylprolyl isomerase D (cyclophilin D)	[27]
Fatty acid oxidation	ACADL	Long-chain Acyl-CoA dehydrogenase (LCAD)	[31]
Ketone body synthesis	HMGCS2	3-Hydroxy-3-methylglutaryl-CoA synthase 2, mitochondrial	[35]
Acetate metabolism	ACSS2	Acyl-CoA synthetase short-chain family member 2	[33,34]
Urea cycle	OTC	Ornithine transcarbamylase	[37]
Amino acid catabolism	GLUD1	Glutamate dehydrogenase 1 (GDH)	[15]
Mitochondrial protein synthesis	MRPL10	Mitochondrial ribosomal protein L10	[38]
Oxidative phosphorylation	NDUFA9	NADH dehydrogenase (ubiquinone) 1 α subcomplex 9	[40]
	SDHA	Succinate dehydrogenase complex, subunit A, flavoprotein	[41,42]
	ATP5a	F1F0-ATPase subunit α	[43]
TCA cycle	IDH2	Isocitrate dehydrogenase 2, mitochondrial	[44]
Oxidative stress
Transcriptional activation	FOXO3a	Forkhead box O3a	[17,58]
ROS	SOD2	Superoxide dismutase 2, mitochondrial (MnSOD)	[53–57]
Apoptosis	OPA1	Optic atrophy 1	[59,60]
	XRCC6	X-ray repair cross-complementing 6 (Ku70)	[58]