Review Article
SIRT3: A New Regulator of Cardiovascular Diseases
Table 1
Known targets of SIRT3 and function.
| Function | Gene symbol | Gene name | References |
| Energy metabolism | Glycolysis | PPID | Peptidylprolyl isomerase D (cyclophilin D) | [27] | Fatty acid oxidation | ACADL | Long-chain Acyl-CoA dehydrogenase (LCAD) | [31] | Ketone body synthesis | HMGCS2 | 3-Hydroxy-3-methylglutaryl-CoA synthase 2, mitochondrial | [35] | Acetate metabolism | ACSS2 | Acyl-CoA synthetase short-chain family member 2 | [33,34] | Urea cycle | OTC | Ornithine transcarbamylase | [37] | Amino acid catabolism | GLUD1 | Glutamate dehydrogenase 1 (GDH) | [15] | Mitochondrial protein synthesis | MRPL10 | Mitochondrial ribosomal protein L10 | [38] | Oxidative phosphorylation | NDUFA9 | NADH dehydrogenase (ubiquinone) 1 α subcomplex 9 | [40] | SDHA | Succinate dehydrogenase complex, subunit A, flavoprotein | [41,42] | ATP5a | F1F0-ATPase subunit α | [43] | TCA cycle | IDH2 | Isocitrate dehydrogenase 2, mitochondrial | [44] | Oxidative stress | Transcriptional activation | FOXO3a | Forkhead box O3a | [17,58] | ROS | SOD2 | Superoxide dismutase 2, mitochondrial (MnSOD) | [53–57] | Apoptosis | OPA1 | Optic atrophy 1 | [59,60] | XRCC6 | X-ray repair cross-complementing 6 (Ku70) | [58] |
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