SIRT3: A New Regulator of Cardiovascular Diseases

Table 2

Therapeutic application of SIRT3.

Categories	Representatives	Mechanism	References
Traditional Chinese medicine	Resveratrol	↑SIRT3; ↓TGF-β/Smad3	[113–115]
	Polydatin	↑SIRT3	[116]
	Berberine	↑SIRT3	[117]
	Honokiol	↑SIRT3	[76,118]
	Pomegraniin A	↑SIRT3/SOD2	[119]
	Oroxylin A	↑SIRT3	[120,121]
	Curcumin	↑PGC-1α/SIRT3	[122]
Small molecule activators of SIRT3	↓PIKFYVE	↑SIRT3	[123]
	Melatonin	↑SIRT3	[79, 104, 124, 125]
	Adjudin	↑SIRT3	[126]
	Minocycline	↑SIRT3/PHD2; ↓HIF-1α	[127]
	MIPEP	↑SIRT3	[128]
	Metformin	↑SIRT3	[129]
	NMNAT3	↑NAD^+/SIRT3	[84]
	C12	↑SIRT3/MnSOD	[138]
Signaling pathways	EphB2 signaling	↑SIRT3/MnSOD	[139]
	cAMP/PKA signaling	↑SIRT3/OPA1	[59]
	AMPK	↑SIRT3	[140]
	SIRT1	↑SIRT3	[141]
	PLGA-PNIPAM-NaB	↑SIRT3	[142]
	PGC-1α-HO-1	↑SIRT3	[143]
MicroRNAs	MicroRNA-210	↓SIRT3	[144]
	MicroRNA-92a	↓SIRT2 (Drosophila, homologous to human SIRT2 and SIRT3)	[145]
	MicroRNA28-5p	↓SIRT3	[146]
	MicroRNA-421	↓SIRT3/FOXO3	[147]