Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2-Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action

Figure 1

Schematic model of the regulation of the Nrf2 signaling pathway. Under basal conditions, Nrf2 undergoes Keap1-mediated ubiquitylation and 26S proteasome-mediated degradation. In response to oxidants, toxicants, or Nrf2 inducers, Nrf2 is released from Keap1, translocates into the nucleus, and activates the transcription of ARE-mediated protective genes.