Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice

Figure 5

Cardiac levels of nitric oxide (NO), lipid, protein, and DNA markers of oxidative tissue damage in mice infected with Trypanosoma cruzi and treated with the nonselective purinergic antagonist suramin. NO was estimated as nitrite/nitrate (NO₂⁻/NO₃⁻) levels. MDA, malondialdehyde. Oxidized proteins were estimated as protein carbonyl levels. 8-OHdG, 8-hydroxy-2-deoxyguanosine. SAL: 0.9% NaCl solution; INF: untreated and infected; SR5, SR10, and SR20: infected and treated with 5, 10, or 20 mg suramin/kg, respectively.