Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in <i>Trypanosoma cruzi</i>-Infected Mice

<div>Enzymatic and nonenzymatic antioxidant defenses in mice infected with <i>Trypanosoma cruzi</i> and treated with the nonselective purinergic antagonist suramin. GST: Glutathione-S-transferase; SOD: superoxide dismutase. SAL: 0.9% NaCl solution; INF: untreated and infected; SR5, SR10, and SR20: infected and treated with 5, 10, or 20 mg suramin/kg, respectively.</div>

Oxidative Medicine and Cellular Longevity

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Figure 6

Figure 6: Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in <i>Trypanosoma cruzi</i>-Infected Mice 

Figure 6 | Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice 