Acute Hyperbaric Oxygenation, Contrary to Intermittent Hyperbaric Oxygenation, Adversely Affects Vasorelaxation in Healthy Sprague-Dawley Rats due to Increased Oxidative Stress

Table 4

Relative expression of SOD1, 2, and 3, CAT, GPx1, GPx4, eNOS, iNOS, and NADPH oxidase component (p47phox and gp91phox) mRNAs in aortas.

Group	SOD1	SOD2	SOD3	CAT	GPx1	GPx4	eNOS	iNOS	p47phox	gp91x
CTRL	0.85 ± 0.15	0.43 ± 0.13	0.49 ± 0.15	0.42 ± 0.10	1.84 ± 0.65	0.35 ± 0.08	0.13 ± 0.06	0.38 ± 0.07	5.21 ± 1.22	0.10 ± 0.02
A-HBO2	0.82 ± 0.13	0.48 ± 0.16	0.46 ± 0.08	0.76 ± 0.18	3.51 ± 1.22	0.31 ± 0.11	0.03 ± 0.02	0.11 ± 0.02	3.87 ± 0.44	0.68 ± 0.21
24H-HBO2	0.86 ± 0.10	0.97 ± 0.23	0.82 ± 0.08	1.12 ± 0.18	2.72 ± 0.50^†	0.63 ± 0.07^†	0.13 ± 0.06	0.12 ± 0.03	4.44 ± 0.49	1.07 ± 0.11^†
4D-HBO2	1.77 ± 0.20^†‡	0.40 ± 0.15	1.49 ± 0.33^†‡	1.66 ± 0.16^†‡	10.86 ± 1.84^†‡	0.48 ± 0.14^†	0.04 ± 0.02	0.21 ± 0.05	6.96 ± 0.67^†‡	1.95 ± 0.34^†‡

Data are presented as (standard error of mean); (number of rats per group). SOD 1, 2, and 3: superoxide dismutase; CAT: catalase; GPx1 and 4: glutathione peroxidase; eNOS: endothelial nitric oxide synthase; iNOS: inducible nitric oxide synthase; p47phox and gp91phox: NADPH oxidase components. compared to the CTRL group; compared to the A-HBO₂ group; and compared to the 24H-HBO₂ group.