The Antidiabetic and Antinephritic Activities of Tuber melanosporum via Modulation of Nrf2-Mediated Oxidative Stress in the db/db Mouse
Table 7
The effects of Tuber melanosporum powder on oxidative stress-related factors in the serum and kidney of mice.
db/+
db/db
0.1 g/kg Met
0.2 g/kg TM
0.4 g/kg TM
Serum
SOD (U/mL)
240.3 ± 5.0
193.6 ± 2.5###
245.7 ± 3.9
206.1 ± 3.9
218.6 ± 5.5
GSH-Px (U/mL)
304.4 ± 9.5
230.8 ± 3.7###
227.2 ± 6.0
248.8 ± 11.6
236.5 ± 5.3
CAT (U/mL)
54.6 ± 1.3
41.2 ± 0.9###
45.2 ± 1. 5
48.3 ± 1.9
48.4 ± 1.1
Kidney
ROS (U/mg)
46.1 ± 1.7
62.6 ± 4.1#
42.1 ± 2.1
51.1 ± 0.5
43.3 ± 3.2
SOD (U/mg)
34.9 ± 2.8
23.3 ± 1.3##
29.4 ± 2.6
37.0 ± 5.0
34.1 ± 4.8
GSH-Px (mg/mL)
75.7 ± 3.9
42.3 ± 1.3###
50.8 ± 3.0
71.6 ± 6.9
67.7 ± 6.4
CAT (U/mg)
8.7 ± 0.5
7.0 ± 0.3#
8.8 ± 0.5
8.9 ± 0.4
9.0 ± 0.3
The data were analyzed using a one-way ANOVA and they are expressed as means ± SEMs (). ,, and versus db/+ mice; ,, and versus nontreated db/db mice. TM: T. melanosporum.
