High-Fat Diet Increases HMGB1 Expression and Promotes Lung Inflammation in Mice Subjected to Mechanical Ventilation

Table 4

Biomarkers of oxidative stress on pulmonary parenchyma.

	CG	DG	MVG	DMVG
SOD (U/mg ptn)	23.33 ± 1.98	28.83 ± 3.60	43.33 ± 7.18^a	37.32 ± 2.19^a
CAT (U/mg ptn)	1.01 ± 0.06	0.57 ± 0.07^a	0.19 ± 0.02^a,b	0.13 ± 0.01^a,b
GSH/GSSG ratio	6.38 ± 1.64	5.47 ± 0.60	1.97 ± 0.18^a	5.05 ± 1.52
TBARS (nmol/mg ptn)	2.42 ± 0.27	2.16 ± 0.21	5.85 ± 1.11^a,b,d	2.77 ± 0.32
Protein carbonyl (nmol/mg ptn)	4.74 ± 0.89	3.45 ± 0.37	14.20 ± 1.64^a,b	18.46 ± 4.34^a,b

(a) represents significant difference between groups when compared to CG. (b) represents significant difference between groups when compared to DG. (d) represents significant difference between groups when compared to DMVG. Data are expressed as mean ± standard error of the mean () and were analyzed by one-way ANOVA followed by Tukey’s posttest (). CG: control group; DG: diet group; MVG: mechanical ventilation group; DMVG: diet mechanical ventilation group; CAT: catalase; GSH: glutathione reduced; GSSG: glutathione oxidized; SOD: superoxide dismutase; TBARS: thiobarbituric acid reactive substances.