Early Prediction of Hypoxic-Ischemic Brain Injury by a New Panel of Biomarkers in a Population of Term Newborns

Table 2

Clinical and biochemical signs of hypoxic-ischemic encephalopathy reported by groups.

	Mild-to-moderate HIE group ()	Severe HIE group ()
Median Apgar 1 min (IR)	2 (1–4)	1 (0–2)	NS
Median Apgar 5 min (IR)	4 (4-5)	3 (1–5)	0.002
Median Apgar 10 min (IR)	7 (5–7)	6 (3–7)	0.011
Mean umbilical pH (SD)	7.0 (0.1)	7.0 (0.2)	NS
Mean umbilical BE (mmol/L) (SD)	−13.7 (6.2)	−13.8 (8.3)	NS
Mean pH at admission (15 min–6 h of life) (SD)	7.1 (0.1)	6.9 (0.2)	0.043
Mean BE at admission (15 min–6 h of life, mmol/L) (SD)	−11.1 (6.7)	−16.3 (7.7)	0.013
Mean lactate at admission (15 min–6 h of life, mmol/L) (SD)	13.6 (5.2)	15.4 (7.8)	NS
Mean PNA at MRI (days) (SD)	3 (2)	6 (4)	NS
Median Thompson score (1 h of life) (IR)	4 (2–5)	9 (7–13)	0.000
Seizures n (%)	2 (9)	27 (54)	0.001

IR: interquartile range; SD: standard deviation. NS: not statistically significant.