Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats

Table 1

Physiological parameters at 0, 2, and 4 weeks.

Week

Control

ANG II-salt

Vehicle

Benzbromarone

Olmesartan

0

2

4

0

2

4

0

2

4

0

2

4

Body weight (g)

209 ± 13

348 ± 16

405 ± 41

205 ± 13

204 ± 33

197 ± 42

205 ± 12

239 ± 31

224 ± 50

208 ± 14

304 ± 14^,#

363 ± 21^#

TP (g/dL)

5.7 ± 0.2

5.8 ± 0.1

6.0 ± 0.2

5.4 ± 0.2

5.7 ± 0.6

5.9 ± 0.5

5.4 ± 0.3

5.5 ± 0.6

6.1 ± 0.8

5.6 ± 0.1

6.0 ± 0.4

6.4 ± 0.4

UA (mg/dL)

0.48 ± 0.14

0.78 ± 0.34

0.68 ± 0.19

0.49 ± 0.22

0.63 ± 0.59

1.77 ± 1.22

0.53 ± 0.27

0.89 ± 0.43

1.04 ± 0.29

0.40 ± 0.14

0.92 ± 0.44

0.56 ± 0.34^#

Cr (mg/dL)

0.54 ± 0.12

0.79 ± 0.17

0.45 ± 0.12

0.50 ± 0.23

0.74 ± 0.23

0.84 ± 0.48

0.61 ± 0.18

0.47 ± 0.35

0.95 ± 0.69

0.48 ± 0.07

0.87 ± 0.59

0.61 ± 0.37

BUN (mg/dL)

22.1 ± 10.9

16.5 ± 3.0

22.1 ± 3.4

22.6 ± 10.2

35.5 ± 10.2^∗

42.0 ± 33.8

20.4 ± 6.9

39.6 ± 6.3^∗

42.2 ± 21.1

18.1 ± 7.4

21.5 ± 4.8^#

24.5 ± 6.3

AST (IU/L)

28.8 ± 1.8

30.6 ± 4.9

28.8 ± 3.6

31.2 ± 3.8

29.5 ± 2.5

31.6 ± 10.2

30.9 ± 3.6

34.8 ± 12.1

42.0 ± 19.6

29.6 ± 4.0

32.9 ± 3.3

27.5 ± 2.2

ALT (IU/L)

7.5 ± 1.5

7.6 ± 1.0

8.2 ± 1.1

7.7 ± 0.9

9.7 ± 2.7

18.6 ± 5.6^∗

7.8 ± 1.1

11.1 ± 3.3

16.5 ± 7.2^∗

7.1 ± 1.4

9.3 ± 1.4

9.4 ± 2.1^#

U-pro (mg/day)

4 ± 2

8 ± 2

9 ± 2

4 ± 2

313 ± 170

255 ± 278

4 ± 3

255 ± 100

255 ± 88

5 ± 3

14 ± 8^#

18 ± 11^#

Values are expressed as the means ± SD (control, , others, ). compared with the control group, compared with the vehicle group at the same week.